Schizophrenia is a chronic mental health condition that can cause a range of psychological symptoms which include hallucinations and delusions. A delusion is something which a person believes to be true yet is untrue and a hallucination is hearing or seeing something that is not there or doesn’t exist. These are psychotic symptoms, with psychosis being the inability for a person to distinguish between reality and imagination. There is no exact cause of schizophrenia and no current cure yet is one of the most common serious mental health conditions with one in one hundred people experiencing an episode of schizophrenia within their lifetime.
There are two main explanations of schizophrenia, biological explanation and a psychological explanation. The Biological explanation suggests that behaviour can be related to changes in brain activity and its physiology. If behaviour is associated with changes in brain function then schizophrenia could then be caused by relative size of brain structures (areas) or brain neurotransmitters and hormonal activity. Another cause could be due to genetics. As the development of the body, including the brain is heavily determined by genetic, biological psychology assumes that most behaviours whether seen as ‘normal’ or not are considered to be inherited to an extent in gene form from parents. However no all symptoms could be created by genetic influence, as other factors such as social influences have been shown to change certain physiology such as hormonal and neural-activity. This gives the possibility that environmental and genetic factors could both influence schizophrenia.
Genetic factors can be researched using twin studies, especially those who have been reared apart (to try and prove whether environmental factors have an influence on schizophrenia using studies with adopted children or other cases.) and looking at the differences between monozygous and dyzygous twins. Evidence so far shows that concordance rates for schizophrenia in monozygous twins is much higher that the concordance rate for dizygous twins, providing support for genetic factors. Identical twins (monozygous) who share a one hundred percent gene share, have a forty eight percent chance or risk of both developing schizophrenia, this is much lower in non-identical twins (dizygous) where there is only a seven-teen percent chance or risk of them both developing into sufferers, these only have a fifty percentage gene share.Family studies using biological relatives can also account for research into schizophrenia, with the health condition being more common in biological relatives of a schizophrenic and the greater genetic relatedness the higher the risk of getting the condition.
Schizophrenia is seen to be affected largely by the neurotransmitter dopamine. Dopamine is a neurohormone which is produced in several areas of the brain one area being the substantia nigra. Dopamine is released by the Hypothalamus and its main function is to inhibit the release of prolactin from the pituitary. Schizophrenia has been linked with high amounts of dopamine within the brain. This was discovered after phenothiazines which block dopamine receptors, blocking the transmission of nerve impulses (D2) where shown to lower the symptoms of the health condition. schizophrenia sufferers have been found to have an abnormal amount of ‘D2′ receptors on their receiving neurones. Also the knowledge that drugs such as amphetamine and cocaine which largely increase dopamine levels have been noted for the cause of psychosis. This could explain the problems of attention and thought found in people suffering from schizophrenia as the dopamine neurons play a large role in guiding attention. Alternatively Parkinson’s disease sufferers have a abnormally low number of dopamine activity and increasing the dopamine level within the brain by drug consumption develop signs of schizophrenic-type symptoms.
Brain imaging techniques have helped to discover that many sufferers of schizophrenia have enlarged ventricles and cavities within the brain which supply areas with nutrients and remove waste products such as carbon dioxide. Schizophrenia sufferers ventricles are on average fifteen percent larger then that of a non-sufferer. Sufferers with the enlarge ventricles tend to show signs of the negative symptoms and cognitive disturbances rather than the positive symptoms. It has been suggested that the large ventricles have restricted the growth of brain development or allowed for tissue damage, possibly being the cause of schizophrenia. Brain imaging can also help for research within schizophrenia. Techniques involving PET an other scans have helped to show that the prefrontal cortex shows signs of reduced neural activity within patients suffering from schizophrenia.
Another area within the biological explanation which could explain schizophrenia and brain abnormalities may be caused by exposure to viral infections before birth. These can be dormant until puberty when hormonal changes could then cause the symptoms of the health condition. This can be shown with the evidence that more suffering people with schizophrenia are born within winter months. schizophrenia is most common in people born between December and April, when viral infections are at the highest within the year. When exposure is at its highest, the person will have a larger chance of becoming infected before birth. Evidence for this can be taken from twin studies with schizophrenic twins having fingerprint abnormalities compared to their identical twin. Finger prints are developed during the second trimester of pregnancy, this is when the foetus is at its highest risk of viral infection. Viral infections could have been contracted from the mother. If the mother were to become infected this would increase the chance or risk of the foetus also becoming infected whilst developing in the womb.
There are many different explanations for schizophrenia that take a psychological stance. These contain psychodynamic, cognitive, behavioural and other sociocultural factors. Biological explanations have recently in modern times gained the most research support however psychological explanations still have an influence on understanding schizophrenia. There are two main areas within psychological explanations, those on the psychological side, taking basic psychological perspectives and socio-cultural in where the role of family and in society.
Cognitive explanations acknowledge the role of biological factors for the cause of initial sensory experiences of schizophrenia however further features of the disorder appear as the individual attempts to understand them. It also suggests that schizophrenia is characterised by profound thought disturbance. This could be down to cognitive deficits which can impair areas such as perception and memory. This could form cognitive biases and explain the misconceptions and the way schizophrenic sufferers interpret the world. Schizophrenics usually first discover symptoms of voices and abnormal sensory experiences, this then usually makes them turn to friends and family to confirm the experiences. Those that cannot confirm the reality of the sensory experiences and voices start to believe that they must be hiding the truth. This can then lead to rejection of support and feedback from peers and others around them and so disillusioned beliefs and ideas that they are being manipulated and persecuted that are not true start to be formed. This shows that the basis of schizophrenia is biology based, whether this genetic or not, then other symptoms such as hallucinations and delusions are formed after the failure to not accept the reality, these of which are cognitive.
The behavioural explanation suggests that schizophrenia is a consequence of faulty learning. Children who do not receive small amounts or little reinforcement early in their lives will put larger attention into irrelevant environmental cues. For example: taking attention to the sound of a word rather than its procedural meaning. This behaviour will eventually appear ‘weird’ or strange to others and so will generally be avoided. These strange behaviours may be rewarded by attention and sympathy and so they are reinforced. This can continue until the behaviour becomes so strange that they are then labelled as schizophrenic. This can eventually the behaviour and psychological state deteriates into a psychotic state.
Stephen Freud developed the Psycho-Dynamic approach. In terms of schizophrenia it suggests that the health condition is a results of regression to a pre-ego state and attempts to re-establish ego control. If the life experiences of a schizophrenic sufferer are harsh, for example uncaring parents, then the child may regress to a stage of development before the ego and realistic awareness of the world is properly formed. Schizophrenia is seen as an infantile state and symptoms such as delusions can reflect this primitive condition. Other symptoms such as hallucinations and voices reflect the attempts of the person to re-establish its ego control.
Socio-cultural explanations stress the role of social and family relationships. This can include social labelling, family relationships and life events. A major link in this health condition is the high risk of schizophrenic episodes being linked to the occurrence of stressful life events. These can be discrete stressful experiences such as: deaths of close relatives, brake up of intimate relationships or even job losses. Although the mechanisms of schizophrenia being caused and triggered by stressful experiences has not been identified, high levels of physiological arousal has been seen to be associated with neurotransmitter charges, possibly explaining stressors as a cause.
This explanation can be supported by research that shows that schizophrenic episodes seem to occur fifty percent of the time within three weeks of a major stressful life event such as marriage, house buying or death of a close family member. With twelve percent who suffered having a major life experience within 9 weeks of the episode. This suggests that major life changes can trigger schizophrenic episodes. Other research shows that schizophrenic episodes are more common after a more concentrated period of stressful events.
The family relationship theory suggests that children who frequently receive contradictory messages from their parents are more likely to develop schizophrenia. For example a mother telling a child that she loves them and is proud of them, but at the same time turning away in disgust. This will lead the child to receiving confused and conflicting messages about their relationship, conflict between verbal and non-verbal. A continuum of these contradictions can develop into an abnormal internally coherent construction of reality. Chronically this can develop into schizophrenic symptoms such as delusions and hallucinations.
It also suggests that negative emotional climates or a high degree of expressed emotion can lead to schizophrenia. Expressed emotion is a particular family communication style that involves criticism, hostility and emotional over-involvement. A patient with a family containing high expressed emotion is more likely to relapse or have a schizophrenic episode. The expressed emotion tends to arouse the patients stress levels and so worsens the condition.
Social labelling however was popularised by Scheff. This states that social groups create a concept of psychiatric deviance by constructing rules for group members to follow. Schizophrenic behaviours are seen to ‘deviate’ from the ‘norm’ and so are considered ‘abnormal’ Once the deviating people are labelled schizophrenic, it opens gates and promotes the development of schizophrenic symptoms.
Both biological and psychological explanations try to explain how and why schizophrenia is developed in a hope to try and control or cure the condition. The biological explanations try to explain the health condition in terms of biochemistry and physiology in terms to try and adapt new drugs or techniques to overcome the problems, whereas psychological explanations try to take into account how the behaviours are developed and how environmental factors can be controlled to try and stop the condition. Although both are considered to contradict each others research, in my own opinion schizophrenia seems to be a development of both biological and psychological abnormalities.

schizophrenic Brain Scan
